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Safeguard Scientifics to Release Fourth Quarter and Year-End 2007 Financial Results on Tuesday, April 1st

WAYNE, Pa.-(Business Wire)-March 28, 2008 - Safeguard Scientifics, Inc. (NYSE:SFE), a holding company that builds value in growth-stage technology and life sciences companies, today announced that it will release its financial results for the fourth quarter and year-ended December 31, 2007 prior to market open on Tuesday, April 1, 2008. -0- *T Date: Tuesday, April 1, 2008 Time: 9:00am ET Webcast: www.safeguard.com/earnings Call-in Number: 800-309-8407 (International) +706-643-1196 Replay Number: 800-642-1687 (International) +706-645-9291 Conference ID# 36443065 Podcast: www.safeguard.com/podcast Available within 24 hours following the conclusion of the earnings call. Speakers: President and CEO Peter J. Boni; Senior Vice President and CFO Raymond J. Land Format: Discussion of fourth quarter and year-end 2007 financial results followed by Q&A. *T

About Safeguard Scientifics

Founded in 1953 and based in Wayne, PA, Safeguard Scientifics, Inc. (NYSE:SFE) provides growth capital for entrepreneurial and innovative technology and life sciences companies. Safeguard targets technology companies in Software as a Service (SaaS), Technology-Enabled Services and Internet-based Businesses, and life sciences companies in Molecular and Point-of-Care Diagnostics, Medical Devices and Specialty Pharmaceuticals with capital requirements between $5 and $50 million. Safeguard participates in expansion financings, corporate spin-outs, management buyouts, recapitalizations, industry consolidations and early-stage financings. www.safeguard.com

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