Scarab Genomics Introduces ScarabXpress™ T7lac, a unique E. coli expression strain
MADISON, Wis.-(Business Wire)-September 29, 2009 - ScarabXpress is the latest strain in the multiple-deletion series (MDS) of Scarab Genomics Clean Genome® E. coli. Based on the MDS™42 strain, ScarabXpress T7lac contains a chromosomal copy of the T7 RNA polymerase gene expressed from a unique, tightly controlled lac promoter. MDS™42 is a K-12 strain with a 15% genome reduction to remove non-essential genes, sequences for recombinogenic and mobile DNA, and cryptic virulence genes, while preserving robust growth and protein production. Scarab has removed Insertion sequence (IS) elements, which are a prevalent, but frequently overlooked, problem that contributes to clonal instability. In addition, Clean Genome® strains lack prophage, which can be stress-activated and cause premature lysis and failed runs during fermentation. Genome reduction optimizes Clean Genome E. coli for recombinant DNA and protein production, providing enhanced genetic stability and improved metabolic efficiency, and making them the strains of choice for applications ranging from routine cloning to manufacturing biotherapeutics.
About Scarab Genomics, LLC:
Scarab Genomics, a Madison, WI biotechnology company, offers unique Clean Genome® E. coli Strains for next generation DNA and protein production. Based on Dr. Fred Blattner’s expertise in the new technology of genome engineering, the K-12 genome has been reduced to remove non-essential genes and problematic DNA elements. Genome reduction provides enhanced genetic stability and improved host safety, while retaining robust growth on minimal media, making these strains ideal for biotherapeutic production. Additional reduced strains are currently being produced and tested. Please inquire for additional information.
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